The first ai-designed drug just reached the last trial gate. insilico's rentosertib, with both…
the first ai-designed drug just reached the last trial gate. insilico's rentosertib, with both target discovery and molecular design done by generative ai, began phase three dosing for idiopathic pulmonary fibrosis on september 10, while abbvie paired with iambic on september 21 to speed discovery further.
phase three is where most drugs die, so this one is now the test.
Context
Verified source: Insilico Medicine (Sep 10, 2026) says it dosed the first patient in GENESIS-IPF-3, which it calls the world's first Phase III trial of a generative AI-driven drug, rentosertib for idiopathic pulmonary fibrosis. A HKEX filing the same day announces the same.
Verified source: AbbVie (Sep 21, 2026) announced a multi-year collaboration with Iambic applying Iambic's AI platform to speed up small molecule discovery.
The Sep 10 first dosing, the Phase III stage and the Sep 21 AbbVie and Iambic deal match the sources. 'The first AI-designed drug' and the target discovery plus design claim are Insilico's own description. 'Phase three is where most drugs die' is the author's opinion, not seen in the excerpts read, so unsupported here, not refuted.
Watch next
- Read the trial listing for the Phase III size and endpoints.
Sources
- Insilico Medicine Doses First Patient in GENESIS-IPF-3, Insilicoinsilico.com
- Voluntary announcement, HKEXnewswww1.hkexnews.hk
- Insilico doses first patient in GENESIS-IPF-3, EurekAlerteurekalert.org
- AbbVie and Iambic Announce Collaboration, AbbVienews.abbvie.com
Provenance
The note above is reproduced unedited from the original post, first published on Threads on 24 September 2026 at 17:04 IST. Sources are the papers and datasets the note draws on.
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